Apuestas desafiantes desde su difícil acceso diagnóstico y manejo oncológico de tumores de nasofaringe

Laura Sofía Valderrama Cortázar, Angie Carolina Salas Niño, Lina Tatiana Rodriguez Ojeda, María Paula Herrera Garzón

Resumen


Objetivos: El alto índice de recurrencia de tumores de nasofaringe, así como a su vez el diagnóstico tardío de esta patología infrecuente es un desafío médico en la actualidad. Nuestro objetivo es conocer el avance diagnóstico y terapéutico haciendo uso de técnicas bioquímicas, genéticas, radiológicas y quirúrgicas para el abordaje integral.

Método: Se realizó una revisión de literatura de artículos científicos en bases de datos (PUBMED) publicados durante el año 2019 que incluyeran avances en métodos diagnósticos y terapéuticos.

Conclusiones: El diagnóstico temprano es un pilar para el adecuado enfoque de la patología, la tomografía computarizada, la resonancia magnética y la ultrasonografía contrastada son las herramientas tecnológicas con mayor utilidad. El enfoque de tratamiento incluye la radioterapia de intensidad modulada, la quimioterapia de inducción agregada (tasa de menor toxicidad y efectos adversos) y el manejo quirúrgico endoscópico como una mejor opción que el abordaje abierto. Cabe resaltar la importancia del descubrimiento de marcadores tumorales y genéticos como factores para evaluar eficacia terapéutica, pronóstico y supervivencia.

Palabras clave


Carcinoma, nasofaringe, Epstein Barr, marcadores, endoscopia, tomografia, resonancia.

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Referencias


Nersesyan MV, Kostousova AI, Lubnin AY, Ryzhova MV, Kapitanov DN. Primary juvenile nasal angiofibroma in a 38-year-old male (case report). VestnOtorinolaringol. 2019:

(5):76-80.

Carmen Deus Abelenda, Mercedes Álvarez-Buylla Blanco, Alejandro Martínez Morán Complexo Hospitalario Universitario “Juan Canalejo” – A Coruña. Tumores de la rinofaringe. Cavidad oral y faringe. Seorl Sociedad Española de Otorrinolaringología y Patología Cervico-Facial.Panamericana. 2011.

https://www.ncbi.nlm.nih.gov/books/NBK459256/ [Internet]. Shreya Sinha Ajeet Gajra. SUNY Upstate Medical University. Cancer, Nasopharynx. December 16, 2019.

Li W, Ni Y, Lu H, Hu L, Wang D. Current perspectives on the origin theory of juvenile nasopharyngeal angiofibroma. Discov Med. 2019 Jun;27(150):245-254.

Saleh Mohebbi1, Mohammad Aghajanpour1. From Juvenile Nasopharyngeal Angiofibroma to Nasopharyngeal Carcinoma; A Rare Case Report of Nasopharyngeal Mass. Bull Emerg Trauma. 2019 Oct; 7(4): 424–426.

Flora López. Oncología Médica. Hospital Universitario. El papel de la quimioterapia de inducción en cáncer de nasofaringe. MPG Journal, Julio 2019; 2; 45.

Abdulaziz A. Almobarak, Alaeddin B. Jebreel, Ahmed Abu-Zaid. Molecular Targeted Therapy in the Management of Recurrent and Metastatic Nasopharyngeal Carcinoma: A Comprehensive Literature Review. Cureus. 2019 Mar; 11(3): e4210.

Chien-Yu Hsueh 1,2, Ching-Fen Yang 2,3, Jyh-Pyng Gau 2,4, Edward C. Kuan 5, Ching-Yin Ho 2,6, Tzeon-Jye Chiou 2,7, Liang-Tsai Hsiao 2,4, Ting-An Lin 2,4 and Ming-Ying Lan. Nasopharyngeal Lymphoma: A 22-Year Review of 35 Cases. J Clin Med. 2019 Oct 3;8(10). pii: E1604. doi: 10.3390/jcm8101604

Victor Paul raica1, Ana magdalena bratu2, Constantin zaharia2, Julia alecsandra sălcianu2. CT Evaluation of Squamous Cell Carcinoma of the Nasopharynx. Journal List. Curr Health Sci J. v.45 (1); Jan-Mar 2019. PMC6592665

Fei Z, Chen C, Huang Y, Qiu X, Li Y, Li L, Chen T. Metabolic tumor volume and conformal radiotherapy based on prognostic PET/CT for treatment of nasopharyngeal carcinoma. Medicine (Baltimore). 2019 Jul;98(28):e16327. doi: 10.1097/MD.0000000000016327.

Raghavan Nair JK, Vallières M, Mascarella MA, El Sabbagh N, Duchatellier CF, Zeitouni A, Shenouda G, Chankowsky J. Magnetic Resonance Imaging Texture Analysis Predicts Recurrence in Patients with Nasopharyngeal Carcinoma. Can Assoc Radiol J. 2019 Nov;70(4):394-402. doi: 10.1016/j.carj.2019.06.009. Epub 2019 Sep 11

Gao Y, Lu L, Huang JY, Zhao YH, Chen YH, Zhu SY. Contrast-enhanced ultrasonography of nasopharyngeal carcinoma: enhancement patterns and quantitative parameters. Discov Med. 2019 Jun;27(150):227-233.

Juan Francisco Oré, Acevedo Luis, Martín La Torre, Caballero Rosmery, Janet Urteaga Quiroga. Juvenile nasopharyngeal angiofibroma surgical treatment in paediatric patients. Acta Otorrinolaringologica Española. Vol. 70. Issue 5.pages 279-285 (September - October 2019). Elsevier.

Wang JQ, Han R, Li XP, Zhao YT, Yu XX, Wang XW, Wang K, Li G. The efficacy and safety of salvage surgery for local recurrent nasopharyngeal carcinoma: a systematic review and Meta-analysis. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2019 Sep 7;54(9):676-684. doi: 10.3760/cma.j.issn.1673-0860.2019.09.006

Zhan J, Zhang S, Wei X, Fu Y, Zheng J. Etiology and management of nasopharyngeal hemorrhage after radiotherapy for nasopharyngeal carcinoma. Journal List. Cancer Manag Res. v.11; 2019. PMC6421873

Amran MY, Bahar A. Case Series of Pre-Operative Endovascular Embolization of Nasopharyngeal Angiofibroma Using Polyvinyl Alcohol Foam Particle: A Single Centre Experience. Journal List. Open Access Maced J Med Sci. v.7(15); 2019 Aug 15. PMC6814469

Xiaoni Zhang, BS*, Ning Wu, MD*, Zhipeng Zhao, MS*, Dongmei Han, BS*, Mingyuan He, MD, Wei Yang, BS, Guanghui Cheng, MD, PhD. Fibre-optic endoscope-guided three-dimensional high-dose-rate interstitial brachytherapy for residual nasopharyngeal carcinoma after conventional external beam radiotherapy. J Contemp Brachytherapy. 2019 Jun;11(3):243-249. doi: 10.5114/jcb.2019.86157. Epub 2019 Jun 28

Maroda AJ, Beckmann NA, Sheyn AM, Elijovich L, Michael LM, DiNitto JM, Rangarajan SV.Trimodal embolization of juvenile nasopharyngeal angiofibroma with intracranial extension. Int J Pediatr Otorhinolaryngol. 2019 Dec 4;130:109805. doi: 10.1016/j.ijporl.2019.109805. [Epub ahead of print]

Abdulaziz A. Almobarak, Alaeddin B. Jebreel, Ahmed Abu-Zaid. Molecular Targeted Therapy in the Management of Recurrent and Metastatic Nasopharyngeal Carcinoma: A Comprehensive Literature Review. Journal List Cureusv.11(3); 2019 Mar PMC6505721

Liu F, Luo T, Jin T, Zhang J, Xiang Z, Yan R, Xie L, Wu X, Zhang H, Wang F, Li P, Liu L. Advantages of using reduced-volume intensity modulated radiation therapy for the treatment of nasopharyngeal carcinoma: a retrospective paired study. Journal List BMC Cancerv.19; 2019 PMC6556221

Luo MS, Huang GJ, Liu HB. Oncologic outcomes of IMRT versus CRT for nasopharyngeal carcinoma: A meta-analysis. Medicine (Baltimore). 2019 Jun;98(24):e15951. doi: 10.1097/MD.0000000000015951.

Lee AWM, Ng WT, Chan JYW, Corry J, Mäkitie A, Mendenhall WM, Rinaldo A, Rodrigo JP, Saba NF, Strojan P, Suárez C, Vermorken JB, Yom SS, Ferlito A. Management of locally recurrent nasopharyngeal carcinoma. Cancer Treatment Reviews. Elsevier. Volume 79, September 2019, 101890

Wang K, Dong J, He S, Wang X, Jiang C, Hu P, Guo J, Cai X, Wang X. Comparison of weekly and triweekly cisplatin regimens during concurrent chemo radiotherapy for nasopharyngeal carcinoma. BMC Cancer. 2019 May 22;19(1):482. doi: 10.1186/s12885-019-5688-z.

http://mpgjournal.mpg.es/index.php/journal/article/view/257. [Internet] Flora López López. El papel de la quimioterapia de inducción en cáncer de nasofaringe. Oncología Médica. Hospital Universitario. Vol. 2 Num. 45 (2019)

Vijay M. Patil, Amit Joshi, Vanita Noronha, Vikas Talreja, Vijai Simha, Sachin Dhumal, Bhavesh Bandekar, Arun Chandrasekharan, Kumar Prabhash. Palliative chemotherapy in carcinoma nasopharynx. Journal List South Asian J Cancer v.8 (3); Jul-Sep 2019. PMC6699237

Chen C, Liu SR, Zhou S, Li XH, Wang XH, Tao YL, Chang H, Zhang WW, Li WF, Zhou SL, Xia YF. Recombined humanized endostatin (Endostar) intravenous infusion in the treatment of refractory nasopharyngeal carcinoma: Three case reports. Medicine (Baltimore). 2019 Aug;98(32):e16592. doi: 10.1097/MD.0000000000016592

Chua ML, Sun Y, Supiot S. Advances in nasopharyngeal carcinoma-"West meets East". Br J Radiol. 2019 Oct;92(1102):20199004. doi: 10.1259/bjr.20199004.

Wang D, Luo H, Huo Z, Chen M, Han Z, Hung M, Su B, Li Y, Wang X, Guo X, Xiao H, Lee D, Zhao R, Yang H . Irradiation-induced dynamic changes of gene signatures reveal gain of metastatic ability in nasopharyngeal carcinoma. Journal List Am J Cancer Resv.9(3); 2019.PMC6448059

Guo Y, Zhang Y, Zhang SJ, Ma YN, He Y. Comprehensive analysis of key genes and microRNAs in radioresistant nasopharyngeal carcinoma. Journal List BMC Med Genomics v.12; 2019 PMC6537399

Liu F, Wei J, Hao Y, Tang F, Jiao W, Qu S, He N, Cai Y, Lan J, Yang Y, Wang Y, Li M, Weng J, Li B, Lu J, Han X. Long Noncoding RNAs and Messenger RNAs Expression Profiles Potentially Regulated by ZBTB7A in Nasopharyngeal Carcinoma. Biomed Res Int. 2019 Jun 11;2019:7246491. doi: 10.1155/2019/7246491. eCollection 2019

Zhang JZ, Wu ZH, Cheng Q. Screening and identification of key biomarkers in nasopharyngeal carcinoma: Evidence from bioinformatic analysis. Medicine (Baltimore). 2019 Nov;98(48):e17997. doi: 10.1097/MD.0000000000017997

Tan GW, Sivanesan VM, Abdul Rahman FI, Hassan F, Hasbullah HH, Ng CC, Khoo AS, Tan LP. A novel and non-invasive approach utilizing nasal washings for the detection.

of nasopharyngeal carcinoma. Int J Cancer. 2019 Oct 15;145(8):2260-2266. doi: 10.1002/ijc.32173. Epub 2019 Feb 18

Yang Z, Liu Z. Potentially functional variants of autophagy-related genes are associated with the efficacy and toxicity of radiotherapy in patients with nasopharyngeal carcinoma. Journal List. Mol Genet Genomic Med. v.7(12); 2019 Dec. PMC6900379

Ming‐Zhu Liu| Shuo‐Gui Fang| Wei Huang| Han‐Yu Wang| Yun‐Ming Tian | Run‐Da Huang| Zhuang Sun| Chong Zhao| Tai‐Xiang Lu| Ying Huang| Fei Han. Clinical characteristics and prognostic value of pre‐retreatment plasma epstein‐barr virus DNA in loco regional recurrent nasopharyngeal carcinoma. Cancer Med. 2019 Aug;8(10):4633-4643. doi: 10.1002/cam4.2339. Epub 2019 Jul 3.

Makowska A, Franzen S, Braunschweig T, Denecke B, Shen L1, Baloche V, Busson P, Kontny U. Interferon beta increases NK cell cytotoxicity against tumor cells in patients with nasopharyngeal carcinoma via tumor necrosis factor apoptosis-inducing ligand. Cancer Immunol Immunother. 2019 Aug;68(8):1317-1329. doi: 10.1007/s00262-019-02368-y. Epub 2019 Jul 16.

Liu R, Dow Chan B, Mok DK, Lee CS, Tai WC, Chen S. Arnicolide D, from the herb Centipeda minima, Is a Therapeutic Candidate against Nasopharyngeal Carcinoma. Molecules. 2019 May 17;24(10). pii: E1908. doi: 10.3390/molecules24101908.

Wang D1,2, Luo H1,2, Huo Z2, Chen M3,4, Han Z4, Hung M4,5, Su B1, Li Y6, Wang X7, Guo X8, Xiao H9, Lee D2,3, Zhao R2, Yang H1. Irradiation-induced dynamic changes of gene signatures reveal gain of metastatic ability in nasopharyngeal carcinoma. Am J Cancer Res. 2019; 9(3): 479–495. Published online 2019 Mar 1.

Sun L1, Song J2, Huang Q1. Clinic pathological and prognostic significance of p16 protein in nasopharynx cancer patients: A PRISMA-compliant meta-analysis. Medicine (Baltimore). 2019 Mar;98(11):e14602. doi: 10.1097/MD.0000000000014602.

Xu J1, Ying Y2, Xiong G1, Lai L3, Wang Q1, Yang Y3. Knockdown of serpin peptidase inhibitor clade C member 1 inhibits the growth of nasopharyngeal carcinoma cells. Mol Med Rep. 2019 May;19(5):3658-3666. doi: 10.3892/mmr.2019.10021. Epub 2019 Mar 14.

Chai SJ1, Ahmad Zabidi MM1,2, Gan SP1, Rajadurai P3, Lim PVH4, Ng CC2, Yap LF1, Teo SH1, Lim KP1, Patel V1, Cheong SC1. An Oncogenic Role for Four-Jointed Box 1 (FJX1) in Nasopharyngeal Carcinoma.Volume 2019 |ArticleID 3857853 | 10 pages | https://doi.org/10.1155/2019/3857853

Jiang, F., Yu, W., Zeng, F. et al. PD-1 high expression predicts lower local disease control in stage IV M0 nasopharyngeal carcinoma. BMC Cancer 19, 503 (2019). https://doi.org/10.1186/s12885-019-5689-y

Yang JH1, Lin LK1, Zhang S2. Effects of DACT1 methylation status on invasion and metastasis of nasopharyngeal carcinoma. Biol Res. 2019 Jun 10;52(1):31. doi: 10.1186/s40659-019-0238-3.

Wang M1, Ji YQ1, Song ZB2, Ma XX3, Zou YY4, Li XS1. Knockdown of lncRNA ZFAS1 inhibits progression of nasopharyngeal carcinoma by sponging miR-135a. Neoplasm. 2019 Jun 29;66(6):939-945. doi: 10.4149/neo_2018_181213N963. Print 2019 Nov.

Luo X1,2,3,4, Li N5,6,7, Zhao X5,6,7, Liao C5,6,7, Ye R5,6,7, Cheng C5,6,7, Xu Z8, Quan J5,6,7, Liu J9, Cao Y5,6,7,10. DHRS2 mediates cell growth inhibition induced by Trichothecin in nasopharyngeal carcinoma. J Exp Clin Cancer Res. 2019; 38: 300. Published online 2019 Jul 10. doi: 10.1186/s13046-019-1301-1

Zhang, W., Guo, Q., Liu, G., Zheng, F., Chen, J., Huang, D., Ding, L., Yang, X., Song, E., Xiang, Y., & Yao, H. (2019). NKILA represses nasopharyngeal carcinoma carcinogenesis and metastasis by NF-κB pathway inhibition. PLoS genetics, 15(8), e1008325. https://doi.org/10.1371/journal.pgen.1008325

Chen X1, Li J2, Zhang S3, Xu W4, Shi D1, Zhuo M4, Liang S4, Lei W5, Xie C6. MicroRNA 30a regulates cell proliferation, migration, invasion and apoptosis in human nasopharyngeal carcinoma via targeted regulation of ZEB2. Mol Med Rep. 2019 Aug;20(2):1672-1682. doi: 10.3892/mmr.2019.10387. Epub 2019 Jun 14.

Cen, R. X., & Li, Y. G. (2019). Platelet-to-lymphocyte ratio as a potential prognostic factor in nasopharyngeal carcinoma: A meta-analysis. Medicine, 98(38),e17176. https://doi.org/10.1097/MD.0000000000017176

Yang J1,2, Hu M2, Bai X2, Ding X2, Xie L3, Ma J4, Fan B2, Yu J2. Plasma levels of soluble programmed death ligand 1 (sPD-L1) in WHO II/III nasopharyngeal carcinoma (NPC): A preliminary study. Medicine (Baltimore). 2019 Sep;98(39):e17231. doi: 10.1097/MD.0000000000017231.

Xu, J., Ying, Y., Xiong, G., Lai, L., Wang, Q., & Yang, Y. (2019). Amyloid β precursor protein silencing attenuates epithelial mesenchymal transition of nasopharyngeal carcinoma cells via inhibition of the MAPK pathway. Molecular medicine reports, 20(1), 409–416. https://doi.org/10.3892/mmr.2019.10293

Zeng Y1, Wang S2, Feng M2, Shao Z2, Yuan J2, Shen Z2, Jie W2. [Quantitative proteomics and differential signal enrichment in nasopharyngeal carcinoma cells with or without SETD2 gene knockout]. Nan Fang Yi Ke Da Xue Xue Bao. 2019 Oct 30;39(10):1191-1199. doi: 10.12122/j.issn.1673-4254.2019.10.10

Zhang Q1, Cao WS1, Wang XQ1, Zhang M1, Lu XM1, Chen JQ1, Chen Y1, Ge MM1, Zhong CY1,2, Han HY3. Genistein inhibits nasopharyngeal cancer stem cells through sonic hedgehog signaling. Phytother Res. 2019 Oct;33(10):2783-2791. doi: 10.1002/ptr.6464. Epub 2019 Jul 24.

Xiao B1, Zhang W1, Kuang Z1, Lu J2, Li W2, Deng C2, He Y1, Lei T1, Hao W3, Sun Z1, Li L4. SOX9 promotes nasopharyngeal carcinoma cell proliferation, migration and invasion through BMP2 and mTOR signaling. Gene. 2019 Oct 5;715:144017. doi: 10.1016/j.gene.2019.144017. Epub 2019 Jul 26.

Yin W1, Shi L2, Mao Y1. MicroRNA-449b-5p suppresses cell proliferation, migration and invasion by targeting TPD52 in nasopharyngeal carcinoma. J Biochem. 2019 Nov 1;166(5):433-440. doi: 10.1093/jb/mvz057.

Zhang, X., Qin, Y. Y., Chen, M., Wu, Y. Y., & Lin, F. Q. (2019). Combined Use of Mean Platelet Volume/Platelet Count Ratio and Platelet Distribution Width to Distinguish Between Patients with Nasopharyngeal Carcinoma, Those with Benign Tumors of the Nasopharynx, and Healthy Subjects. Cancer management and research, 11, 10375–10382. https://doi.org/10.2147/CMAR.S226050

Jin, X., Ma, Y. C., Zhu, W. Y., & Fan, L. (2019). CUL4A expression is associated with tumor stage and prognosis in nasopharyngeal carcinoma. Medicine, 98(51), e18036. https://doi.org/10.1097/MD.0000000000018036

He F. et al. (2019) Anti-Cancer Mechanisms of Taurine in Human Nasopharyngeal Carcinoma Cells. In: Hu J., Piao F., Schaffer S., El Idrissi A., Wu JY. (eds) Taurine 11. Advances in Experimental Medicine and Biology, vol 1155. Springer, Singapore

Hsu YB1,2, Huang CF2,3, Lin KT4, Kuo YL5, Lan MC6,7, Lan MY1,8. Podoplanin, a Potential Therapeutic Target for Nasopharyngeal Carcinoma. Volume 2019 |Article 7457013 | 9 pages | https://doi.org/10.1155/2019/7457013


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